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1.CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开
标题翻译: 碳氢化合物的联苯四唑 - 吡唑并吡啶调节剂公开(公告)号:US20080200454A1
公开(公告)日:2008-08-21
申请号:US12031010
申请日:2008-02-14
申请人: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
发明人: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
IPC分类号: A61K31/437 , A61P37/00 , A61P29/00 , A61P1/00 , A61P25/00 , A61P35/00 , A61K31/496 , A61K31/541 , A61K31/55 , A61P17/00 , A61P3/10 , A61P11/00 , C07D471/04 , A61K31/53
CPC分类号: C07D471/04 , C07D519/00
摘要: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译: 描述了碳连接的四氢 - 吡唑并 - 吡啶化合物,其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态,病症和病症的药物组合物和方法,例如银屑病,疼痛,多发性硬化,动脉粥样硬化和类风湿性关节炎。
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公开(公告)号:US07429591B2
公开(公告)日:2008-09-30
申请号:US11517518
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , C07D403/12
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US07417046B2
公开(公告)日:2008-08-26
申请号:US11517145
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , C07D401/14 , C07D413/14 , C07D403/14
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US07589202B2
公开(公告)日:2009-09-15
申请号:US11517062
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: C07D403/06
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号:US20080300255A1
公开(公告)日:2008-12-04
申请号:US12220516
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , A61P37/00
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US20080293732A1
公开(公告)日:2008-11-27
申请号:US12220539
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/496 , A61P37/00
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US07393850B2
公开(公告)日:2008-07-01
申请号:US11517212
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/4965 , C07D401/02 , C07D403/04
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US07772236B2
公开(公告)日:2010-08-10
申请号:US12220539
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , A61K31/24 , A61K31/505
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫疾病的方法。
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公开(公告)号:US07388011B2
公开(公告)日:2008-06-17
申请号:US11517171
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/495 , C07D471/04
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号:US07332494B2
公开(公告)日:2008-02-19
申请号:US10075673
申请日:2002-02-13
申请人: J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
发明人: J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
IPC分类号: A61K31/497 , A61K31/50 , A61K31/53 , A61K31/505
CPC分类号: C07D231/12 , C07D471/04
摘要: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译: 一种使用取代的吡唑治疗过敏性疾病(包括特应性过敏症状)的方法。
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