公开(公告)号：US20210268086A1

公开(公告)日：2021-09-02

申请号：US17255949

申请日：2019-06-27

Applicant: ModernaTX, Inc.

Inventor： Shan Zhong ,  Benjamin Breton ,  Iain Mcfadyen ,  Kristen Hopson ,  Vincent Luczkow ,  Maija Garnaas

IPC: A61K39/00 ,  G16B20/20 ,  G16B20/30 ,  G16B30/00 ,  G01N33/50 ,  G16B40/00 ,  A61P35/00 ,  A61P37/04

Abstract: The disclosure relates to optimized cancer vaccines, as well as methods of making the vaccines, using the vaccines, and compositions comprising the vaccines. The cancer vaccines comprise personalized cancer antigens or portions of cancer hotspot antigens. Additionally, the disclosure relates to a computerized system for selecting nucleic acids to include in an optimized cancer vaccine.