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公开(公告)号：US20150246006A1
公开(公告)日：2015-09-03
申请号：US14700316
申请日：2015-04-30
IPC分类号： A61K9/70 , A61K31/137 , A61F13/02 , A61K31/565
CPC分类号： A61K9/7061 , A61F13/0276 , A61F13/0283 , A61F13/0289 , A61F2013/0296 , A61K9/7053 , A61K9/7092 , A61K31/00 , A61K31/137 , A61K31/565 , A61K47/10 , A61K47/12
摘要： Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
摘要翻译： 公开了透皮递送系统，其包括背衬层，背衬层内的聚合物膜，用于将递送系统附着到患者皮肤或粘膜的粘合剂层，以及在使用之前覆盖粘合剂层的可释放层，所述聚合物膜浸渍 足够的流体介质来改变活性剂通过聚合物膜的传播速率，流体介质的量大于干燥时由流体膜保留的量。
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公开(公告)号：US20170049724A1
公开(公告)日：2017-02-23
申请号：US15218620
申请日：2016-07-25
发明人： Pavan Bhat , Sarat J. Chattaraj , Andrew A. Shaw
IPC分类号： A61K31/138 , A61K9/50
CPC分类号： A61K31/138 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5073 , A61K9/5084
摘要： Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.
摘要翻译： 提供了包含持续释放颗粒的药物制剂，其各自具有包含活性药物成分的内芯珠，基本上围绕内芯珠的中间涂层，以及基本上围绕包含pH独立聚合物的中间涂层的外涂层。 还提供了包含两个珠粒的药物制剂，其中第一和第二珠粒中的每一个具有不同的药物释放曲线。 还提供了制备包含一个或多个珠粒的延长释放剂量组合物的方法。
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