公开(公告)号：US10251868B2

公开(公告)日：2019-04-09

申请号：US15876619

申请日：2018-01-22

Applicant: NOVARTIS AG

Inventor： Jun Cao ,  Bernhard Erb ,  Robin Alec Fairhurst ,  Arnaud Grandeury ,  Shinji Hatakeyama ,  Magdalena Koziczak-Holbro ,  Xinzhong Lai ,  Philipp Lustenberger ,  Bernd Ulrich Riebesehl ,  Nicola Tufilli ,  Thomas Ullrich ,  Xiang Wu ,  Jianguang Zhou

IPC: A61K31/428 ,  A61K31/167 ,  C07D277/68 ,  C07C53/10 ,  A61K45/06

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

公开(公告)号：US10059670B2

公开(公告)日：2018-08-28

申请号：US15684419

申请日：2017-08-23

Applicant: NOVARTIS AG

Inventor： Bernhard Erb ,  Isabelle Sylvie Gallou ,  Florian Karl Kleinbeck-Riniker

IPC: C07D417/14 ,  C07D417/04 ,  C07D213/26

CPC classification number: C07D213/26 ,  C07D417/04 ,  C07D417/14

Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

公开(公告)号：US09913828B2

公开(公告)日：2018-03-13

申请号：US15178579

申请日：2016-06-10

Applicant: Novartis AG

Inventor： Jun Cao ,  Bernhard Erb ,  Robin Alec Fairhurst ,  Arnaud Grandeury ,  Shinji Hatakeyama ,  Magdalena Koziczak-Holbro ,  Xinzhong Lai ,  Philipp Lustenberger ,  Bernd Ulrich Riebesehl ,  Nicola Tufilli ,  Thomas Ullrich ,  Xiang Wu ,  Jianguang Zhou

IPC: A61K31/428 ,  C07D277/68 ,  A61K45/06 ,  A61K31/167 ,  C07C53/10

CPC classification number: A61K31/428 ,  A61K31/167 ,  A61K45/06 ,  C07B2200/07 ,  C07C53/10 ,  C07D277/68 ,  Y02P20/55

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

公开(公告)号：US20170355677A1

公开(公告)日：2017-12-14

申请号：US15684419

申请日：2017-08-23

Applicant: NOVARTIS AG

Inventor： Bernhard Erb ,  Isabelle Sylvie Gallou ,  Florian Karl Kleinbeck-Riniker

IPC: C07D213/26

CPC classification number: C07D213/26 ,  C07D417/04 ,  C07D417/14

Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

公开(公告)号：US09776966B2

公开(公告)日：2017-10-03

申请号：US15480835

申请日：2017-04-06

Applicant: Novartis AG

Inventor： Bernhard Erb ,  Isabelle Sylvie Gallou ,  Florian Karl Kleinbeck

IPC: C07D417/04 ,  C07D417/14 ,  C07D211/72 ,  C07D211/84 ,  C07D213/26

CPC classification number: C07D213/26 ,  C07D417/04 ,  C07D417/14

Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

公开(公告)号：US20170240509A1

公开(公告)日：2017-08-24

申请号：US15480835

申请日：2017-04-06

Applicant: Novartis AG

Inventor： Bernhard Erb ,  Isabelle Sylvie Gallou ,  Florian Karl Kleinbeck

IPC: C07D213/26

CPC classification number: C07D213/26 ,  C07D417/04 ,  C07D417/14

Abstract: Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.