公开(公告)号：US20220033407A1

公开(公告)日：2022-02-03

申请号：US17414672

申请日：2019-12-13

Applicant: NOVARTIS AG

Inventor： Mihai D. Azimioara ,  Bei Chen ,  Robert Epple ,  Declan Hardy ,  Ayako Honda ,  Philip Lam ,  Hasnain Ahmed Malik ,  Fabio Meier ,  Truc Ngoc Nguyen ,  Barun Okram ,  Sejal Patel ,  Rodrigo Rodriguez ,  Duncan Shaw ,  Yiping Shen ,  Baogen WU

IPC: C07D487/10 ,  C07D401/04 ,  C07D213/74 ,  C07D413/04 ,  C07D491/107 ,  A61K45/06

Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.