专利检索 ap:("Nigel W. Bunnett" OR "Christopher J.H. Porter" OR "Derek Cole" OR "Gareth Hicks" OR "Junya Shirai" OR "Gavin Hirst" OR "Takeda Pharmaceutical Company Limited") AND inv:"Christopher J.H. Porter" 第 1 页

1.

发明申请
TRIPARTITE MODULATORS OF ENDOSOMAL G PROTEIN-COUPLED RECEPTORS 审中-公开

公开(公告)号：US20190000981A1

公开(公告)日：2019-01-03

申请号：US16064061

申请日：2016-12-21

申请人： Nigel W. Bunnett , Christopher J.H. Porter , Derek Cole , Gareth Hicks , Junya Shirai , Gavin Hirst , Takeda Pharmaceutical Company Limited

发明人： Nigel W. Bunnett , Christopher J.H. Porter , Derek Cole , Gareth Hicks , Junya Shirai , Gavin Hirst

IPC分类号： A61K47/54 , A61K47/60 , A61K31/575 , A61K31/44 , A61P43/00

摘要： The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.