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1.(5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment 有权
标题翻译: (5s,8s)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮 一(化合物A)用于治疗公开(公告)号:US09212140B2
公开(公告)日:2015-12-15
申请号:US13983165
申请日:2012-02-03
申请人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号: A61K31/4015 , A61K31/403 , A61K45/06 , A01N43/12 , A01N43/38 , C07D209/54
CPC分类号: C07D209/54 , A61K31/4015 , A61K45/06
摘要: The invention relates to (5s,8s)-3-(4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译: 本发明涉及(5s,8s)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂螺[4.5] en-2-one用于治疗目的,用于药物组合物及其在治疗中的用途,特别是用于预防和治疗肿瘤病症。
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2.(5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT 有权
标题翻译: (5S,8S)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂[4.5] DEC-3-EN- 一(化合物A)治疗公开(公告)号:US20140031407A1
公开(公告)日:2014-01-30
申请号:US13983165
申请日:2012-02-03
申请人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号: C07D209/54
CPC分类号: C07D209/54 , A61K31/4015 , A61K45/06
摘要: The invention relates to (5s,8s)-3-(4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译: 本发明涉及(5s,8s)-3-(4'-氯-3'-氟-4-甲基联苯-3-基)-4-羟基-8-甲氧基-1-氮杂螺[4.5] en-2-one用于治疗目的,用于药物组合物及其在治疗中的用途,特别是用于预防和治疗肿瘤病症。
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公开(公告)号:US20130040935A1
公开(公告)日:2013-02-14
申请号:US13578914
申请日:2011-02-08
申请人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人: Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号: A61K31/4015 , C07D209/54 , C07D207/38 , C07D513/04 , C07D209/96 , C07D491/113 , C07D307/94 , C07D307/33 , C07D498/04 , A61K31/407 , A61K31/403 , A61K31/542 , A61K31/365 , A61K31/382 , A61K31/553 , A61P35/00 , C07D491/107
CPC分类号: C07D493/10 , C07D207/38 , C07D209/54 , C07D513/04
摘要: The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译: 本发明涉及用于治疗目的的5'-联苯取代的环酮醇酯,药物组合物及其在治疗中的用途,特别是用于预防和治疗肿瘤病症。
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公开(公告)号:US20120129833A1
公开(公告)日:2012-05-24
申请号:US13213436
申请日:2011-08-19
申请人: Ningshu LIU , Kai Thede , Philip Lienau , Arne Scholz , Maher Najjar , Ulf Bomer , Knut Eis , Reiner Fischer
发明人: Ningshu LIU , Kai Thede , Philip Lienau , Arne Scholz , Maher Najjar , Ulf Bomer , Knut Eis , Reiner Fischer
IPC分类号: A61K31/553 , A61K31/407 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , A61P9/00 , C07D209/54 , A61K31/403 , C07D207/38 , A61K31/4015 , C07D491/113 , C07D307/94 , A61K31/365 , C07D493/10 , C07D487/04 , A61K31/5025 , C07D498/04 , A61K31/4162 , C07D231/34 , A61K31/4152 , C07D221/20 , A61K31/438 , C07D491/107
CPC分类号: C07D207/38 , C07D209/54 , C07D221/20 , C07D231/34 , C07D307/94 , C07D487/04 , C07D491/107 , C07D491/113 , C07D498/04
摘要: The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system.
摘要翻译: 本发明涉及用于治疗目的的5'-联苯取代的环酮酮醇,药物组合物及其在治疗中的用途,特别是用于预防和治疗糖尿病,肥胖症,高脂血症,脂肪肝和心血管系统疾病。
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