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公开(公告)号：US20250049935A1
公开(公告)日：2025-02-13
申请号：US18720511
申请日：2022-12-16
Applicant: Northeastern University
Inventor： Ke Zhang , Yuyan Wang
IPC: A61K47/60 , A61K45/06 , C12N15/115
Abstract: Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.
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