公开(公告)号：US11306075B2

公开(公告)日：2022-04-19

申请号：US16471424

申请日：2017-12-18

申请人： OLIGOMERIX INC.

发明人： Eliot J. Davidowitz ,  James G. Moe ,  Allen B. Reitz ,  Haiyan Bian ,  Charles Gluchowski ,  James Hendrix ,  Albert S. Yehaskel ,  Mark E. McDonnell ,  H. Marie Loughran

IPC分类号： C07D409/14 ,  C07D307/80 ,  C07D405/14

摘要： Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

公开(公告)号：US20240158379A1

公开(公告)日：2024-05-16

申请号：US17721178

申请日：2022-04-14

申请人： OLIGOMERIX INC.

发明人： Eliot J. Davidowitz ,  James G. Moe ,  Allen B. Reitz ,  Haiyan Bian ,  Charles Gluchowski ,  James Hendrix ,  Albert S. Yehaskel ,  Mark E. McDonnell ,  H. Marie Loughran

IPC分类号： C07D409/14 ,  C07D307/80 ,  C07D405/14

CPC分类号： C07D409/14 ,  C07D307/80 ,  C07D405/14

摘要： Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

公开(公告)号：US20210130335A1

公开(公告)日：2021-05-06

申请号：US16471424

申请日：2017-12-18

申请人： OLIGOMERIX INC.

发明人： Eliot J. Davidowitz ,  James G. Moe ,  Allen B. Reitz ,  Haiyan Bian ,  Charles Gluchowski ,  James Hendrix ,  Albert S. Yehaskel ,  Mark E. McDonnell ,  Marie H. Loughran

IPC分类号： C07D409/14 ,  C07D307/80 ,  C07D405/14

摘要： Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

公开(公告)号：US20240158357A1

公开(公告)日：2024-05-16

申请号：US17967344

申请日：2022-10-17

申请人： OLIGOMERIX INC.

发明人： Eliot J. Davidowitz ,  James G. Moe ,  Allen B. Reitz ,  Haiyan Bian ,  Charles Gluchowski ,  James Hendrix ,  Albert S. Yehaskel ,  Mark E. McDonnell ,  H. Marie Loughran

IPC分类号： C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  C07D495/04

CPC分类号： C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  C07D495/04 ,  A61K45/06

摘要： Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

公开(公告)号：US11472776B2

公开(公告)日：2022-10-18

申请号：US16471363

申请日：2017-12-18

申请人： OLIGOMERIX INC.

发明人： Eliot J. Davidowitz ,  James G. Moe ,  Allen B. Reitz ,  Haiyan Bian ,  Charles Gluchowski ,  James Hendrix ,  Albert S. Yehaskel ,  Mark E. McDonnell ,  H. Marie Loughran

IPC分类号： C07D401/04 ,  C07D239/91 ,  C07D401/14 ,  C07D471/04 ,  C07D495/04 ,  A61K45/06

摘要： Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.