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公开(公告)号：US20210386823A1
公开(公告)日：2021-12-16
申请号：US17287636
申请日：2019-10-25
Applicant: OSAKA UNIVERSITY , STEMRIM INC.
Inventor： Katsuto TAMAI , Takashi SHIMBO , Eiji SASAKI , Takahiro TSUSHIMA , Takehiko YAMAZAKI
Abstract: The inventors of the present invention searched for a substance that is effective in treating a cartilage disorder, and as a result, found that, in an animal model of joint cartilage deficiency, an HMGB1 fragment peptide having a specific amino acid sequence exhibits the effect of reproducing a healthy cartilage tissue including a hyaline cartilage. Based on this finding, the present invention provides a pharmaceutical composition that contains the specific HMGB1 fragment peptide and that is for preventing and/or treating a cartilage disorder.
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