公开(公告)号：US20150232436A1

公开(公告)日：2015-08-20

申请号：US14184745

申请日：2014-02-20

Applicant: Oryzon Genomics S.A.

Inventor： Jonathan Alleman Baker ,  Julio Castro Palomino ,  Matthew Colin Thor Fyfe ,  Tamara Maes ,  Marc Martinell Pedemonte

IPC: C07D295/195 ,  A61K31/164 ,  A61K31/495 ,  C07D213/38 ,  A61K31/4418 ,  A61K45/06 ,  A61K31/40 ,  C07C215/64 ,  A61K31/135 ,  C07C311/32 ,  A61K31/18 ,  C07C237/20 ,  C07D207/14

CPC classification number: C07D295/195 ,  A61K31/00 ,  A61K31/131 ,  A61K31/135 ,  A61K31/138 ,  A61K31/15 ,  A61K31/164 ,  A61K31/18 ,  A61K31/40 ,  A61K31/4418 ,  A61K31/495 ,  A61K45/06 ,  C07D207/14 ,  C07D213/38

Abstract: The invention relates to methods and compositions for the treatment or prevention of diseases and disorders associated with myeloproliferative disorders. In particular, the invention relates to an LSD 1 inhibitor for use in treating or preventing Philadelphia chromosome negative myeloproliferative disorders.

Abstract translation: 本发明涉及用于治疗或预防与骨髓增生性疾病相关的疾病和病症的方法和组合物。 特别地，本发明涉及用于治疗或预防费城染色体阴性骨髓增生性疾病的LSD1抑制剂。

公开(公告)号：US09908859B2

公开(公告)日：2018-03-06

申请号：US14184745

申请日：2014-02-20

Applicant: Oryzon Genomics S.A.

Inventor： Jonathan Alleman Baker ,  Julio Castro Palomino ,  Matthew Colin Thor Fyfe ,  Tamara Maes ,  Marc Martinell Pedemonte

IPC: A61K31/135 ,  A01N33/02 ,  C07D295/195 ,  A61K31/164 ,  A61K31/495 ,  C07D213/38 ,  A61K31/4418 ,  C07D207/14 ,  A61K31/40 ,  A61K31/18 ,  A61K45/06 ,  A61K31/131 ,  A61K31/138 ,  A61K31/15

CPC classification number: C07D295/195 ,  A61K31/00 ,  A61K31/131 ,  A61K31/135 ,  A61K31/138 ,  A61K31/15 ,  A61K31/164 ,  A61K31/18 ,  A61K31/40 ,  A61K31/4418 ,  A61K31/495 ,  A61K45/06 ,  C07D207/14 ,  C07D213/38

Abstract: The invention relates to methods and compositions for the treatment or prevention of diseases and disorders associated with myeloproliferative disorders. In particular, the invention relates to an LSD 1 inhibitor for use in treating or preventing Philadelphia chromosome negative myeloproliferative disorders.