公开(公告)号：US20240148775A1

公开(公告)日：2024-05-09

申请号：US18547071

申请日：2022-02-25

Applicant: Osaka University

Inventor： Masahito SHIMOJO ,  Satoshi OBIKA ,  Keishiro MISHIMA ,  Misa YOSHIDA

IPC: A61K31/713 ,  A61P35/00 ,  C12N15/113

CPC classification number: A61K31/713 ,  A61P35/00 ,  C12N15/113

Abstract: An oligonucleotide or a pharmacologically acceptable salt thereof according to the present invention contains a nucleotide sequence complementary to a continuous sequence of at least 12 bases in a target region constituted by a base sequence of SEQ ID No. 1, and induces N-exon skipping in human REST pre-mRNA processing. Such oligonucleotides are useful for manufacturing medicines for treatment of cancer, for example.