公开(公告)号：US20180230127A1

公开(公告)日：2018-08-16

申请号：US15751310

申请日：2016-07-29

Applicant: PFIZER INC.

Inventor： DAVID RANDOLPH ANDERSON ,  Kevin Joseph CURRAN ,  Lori Krim GAVRIN ,  Joel Adam GOLDBERG ,  Arthur LEE ,  Michael Dennis LOWE ,  Akshay Patny ,  Betsy Susan PIERCE ,  Eddine SAIAH ,  John David TRZUPEK

IPC: C07D401/12 ,  C07D211/94

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K2300/00 ,  C07D211/94 ,  C07D451/06

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.