公开(公告)号：US20210308276A1

公开(公告)日：2021-10-07

申请号：US16321695

申请日：2017-07-31

Applicant: PFIZER INC.

Inventor： Russell George DUSHIN ,  Daniel P. UCCELLO ,  Jeremy STARR ,  Ye CHE ,  Mark FLANAGAN ,  Jeffrey M. CASAVANT ,  Christopher John O'DONNELL ,  Gary Frederick FILZEN ,  Jennifer YOUNG ,  Joseph A. ABRAMITE ,  Lawrence N. TUMEY ,  Ludivine MOINE ,  Adam Matthew GILBERT ,  Lee R. ROBERTS

IPC: A61K47/68

Abstract: The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone-based conjugation handles.