公开(公告)号：US11433149B2

公开(公告)日：2022-09-06

申请号：US16280366

申请日：2019-02-20

Applicant: PLATINUM OPTICS TECHNOLOGY INC.

Inventor： Yu-Yu Tsai ,  Fu-Yu Chang ,  Chien-Liang Liu

IPC: A61K51/12 ,  G21K5/02 ,  A61B6/00 ,  A61N5/10

Abstract: Provided is a microsphere including a glass sphere core. The glass sphere core includes a first nuclide, a second nuclide and a diffusion region extending inwardly from an outer surface of the glass sphere core, with the second nuclide distributed in the diffusion region. The first nuclide and the second nuclide become radioactive after being activated by neutrons to produce radiations including β-rays or γ-rays, or simultaneously β-rays and γ-rays. A preparation method of a microsphere is also provided.

公开(公告)号：US20200023088A1

公开(公告)日：2020-01-23

申请号：US16280366

申请日：2019-02-20

Applicant: PLATINUM OPTICS TECHNOLOGY INC.

Inventor： Yu-Yu Tsai ,  Fu-Yu Chang ,  Chien-Liang Liu

IPC: A61K51/12 ,  G21K5/02 ,  A61N5/10 ,  A61B6/00

Abstract: Provided is a radioactive microsphere including a glass sphere core. The glass sphere core includes a first seed, a second seed and a diffusion region extending inwardly from an outer surface of the glass sphere core, with the second seed distributed in the diffusion region. The first seed and the second seed become radioactive after being activated by neutrons to produce radiations including β-rays or γ-rays, or simultaneously β-rays and γ-rays. A preparation method of a radioactive microsphere is also provided.

公开(公告)号：US20200155715A1

公开(公告)日：2020-05-21

申请号：US16686429

申请日：2019-11-18

Applicant: PLATINUM OPTICS TECHNOLOGY INC.

Inventor： Yu-Yu Tsai ,  Fu-Yu Chang ,  Chien-Liang Liu

IPC: A61K51/12 ,  A61L27/54 ,  A61L27/34 ,  A61L27/58 ,  A61L27/12 ,  A61L27/02 ,  A61L27/18 ,  A61L27/20 ,  A61L27/16 ,  C03C3/062 ,  C03C4/00 ,  C03C11/00 ,  C03B19/10 ,  C03C23/00

Abstract: Provided is a radioactive microsphere including glass having a structure represented by a formula Ca3Si2O7 and yttrium oxide contained in the glass. The radioactive microsphere has sphericity of from 0.71 to 1, and is radioactive after being activated by neutron irradiation. A method for preparing a radioactive microsphere and a radioactive filler composition is further provided. The present disclosure can be used to treat tumor by delivering radioactive microspheres to the target tissue, and then radioactive microspheres are activated by neutrons to generate radiation. The radioactivity of microspheres disappears over time, and the microspheres were dissolved and absorbed by the bone tissue in the end.