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公开(公告)号:US07521062B2
公开(公告)日:2009-04-21
申请号:US10748071
申请日:2003-12-29
申请人: Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner
发明人: Paul A. Barsanti , Nathan Brammeier , Anthony Diebes , Liana Marie Lagniton , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Casey Philbin , Nicholas Valiante , Allan S. Wagman , Weibo Wang , Amy J. Weiner
IPC分类号: A61K39/00 , A61K31/40 , A61K31/44 , A61K31/175 , A61K39/095 , A61K45/00
CPC分类号: C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00
摘要: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
摘要翻译: 本发明涉及新型免疫增强剂,新型疫苗佐剂,新化合物和药物组合物,通过施用化合物治疗病毒感染(包括HCV)的新方法,以及通过施用化合物调节免疫应答的新方法。
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公开(公告)号:US20050069555A1
公开(公告)日:2005-03-31
申请号:US10748071
申请日:2003-12-29
申请人: Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
发明人: Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
IPC分类号: A61K20060101 , A61K6/00 , A61K31/175 , A61K31/40 , A61K31/44 , A61K39/00 , A61K39/39 , A61P31/12 , C07D207/06 , C07D207/09 , C07D207/14 , C07D207/32 , C07D207/335 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/10 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04
CPC分类号: C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00
摘要: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
摘要翻译: 本发明涉及新型免疫增强剂,新型疫苗佐剂,新化合物和药物组合物,通过施用化合物治疗病毒感染(包括HCV)的新方法,以及通过施用化合物调节免疫应答的新方法。
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公开(公告)号:US20090281100A1
公开(公告)日:2009-11-12
申请号:US12317493
申请日:2008-12-23
申请人: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, JR. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
发明人: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, JR. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/4709
CPC分类号: C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
摘要: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
摘要翻译: 提供了抑制各种酶和治疗各种病症的方法,其包括向受试者施用结构I或IB的化合物,其药学上可接受的盐,其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物,并用于治疗由这些酶介导的病症。
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公开(公告)号:US07470709B2
公开(公告)日:2008-12-30
申请号:US10644055
申请日:2003-08-19
申请人: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
发明人: Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
IPC分类号: A61K31/47
CPC分类号: C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
摘要: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
摘要翻译: 提供了抑制各种酶和治疗各种病症的方法,其包括向受试者施用结构I或IB的化合物,其药学上可接受的盐,其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物,并用于治疗由这些酶介导的病症。
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公开(公告)号:US07671049B2
公开(公告)日:2010-03-02
申请号:US11761937
申请日:2007-06-12
申请人: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
发明人: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
IPC分类号: A61K31/44 , A61K31/445 , A61K31/497
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D453/02 , C07D487/08
摘要: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译: 提供了新的基于吡咯的化合物,组合物和抑制糖原合酶激酶(GSK3)活性并在体内治疗GSK3介导的病症的方法。 本发明的方法,化合物和组合物可以单独使用或与其它药理活性剂组合用于治疗由GSK3活性介导的病症,例如糖尿病,阿尔茨海默病和其他神经变性疾病,肥胖症,动脉粥样硬化性心血管疾病,必需的 高血压,多囊卵巢综合征,X综合征,缺血,创伤性脑损伤,双相情感障碍,免疫缺陷或癌症。
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公开(公告)号:US07250443B2
公开(公告)日:2007-07-31
申请号:US10646625
申请日:2003-08-21
申请人: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
发明人: Manoj C. Desai , Simon Ng , Zhi-Jie Ni , Keith B. Pfister , Savithri Ramurthy , Sharadha Subramanian , Allan S. Wagman
IPC分类号: A61K31/4025 , A61K31/401 , C07D43/02
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D453/02 , C07D487/08
摘要: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译: 提供了新的基于吡咯的化合物,组合物和抑制糖原合酶激酶(GSK3)活性并在体内治疗GSK3介导的疾病的方法。 本发明的方法,化合物和组合物可以单独使用或与其它药理活性剂组合用于治疗由GSK3活性介导的病症,例如糖尿病,阿尔茨海默病和其他神经变性疾病,肥胖症,动脉粥样硬化性心血管疾病,必需的 高血压,多囊卵巢综合征,X综合征,缺血,创伤性脑损伤,双相情感障碍,免疫缺陷或癌症。
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公开(公告)号:US20050215580A1
公开(公告)日:2005-09-29
申请号:US11042474
申请日:2005-01-24
申请人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
发明人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
IPC分类号: A61K31/4745 , C07D471/02 , C07D471/04
CPC分类号: C07D471/04
摘要: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要翻译: 四氢咔啉化合物,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物,单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。
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公开(公告)号:US07855295B2
公开(公告)日:2010-12-21
申请号:US11042474
申请日:2005-01-24
申请人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
发明人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
IPC分类号: A61K31/437 , C07D487/04
CPC分类号: C07D471/04
摘要: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要翻译: 四氢咔啉化合物,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物,单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。
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公开(公告)号:US08173647B2
公开(公告)日:2012-05-08
申请号:US12449286
申请日:2008-02-06
申请人: Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人: Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号: A61K31/5377 , C07D413/14
CPC分类号: C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要: Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译: 磷脂酰肌醇(PI)3-激酶抑制剂化合物,其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性,蛋白质丝氨酸/苏氨酸激酶和磷脂激酶(包括增殖性疾病)的疾病中的用途, 炎性和阻塞性气道疾病,过敏性疾病,自身免疫性疾病和心血管疾病。
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公开(公告)号:US20100048547A1
公开(公告)日:2010-02-25
申请号:US12449286
申请日:2008-02-06
申请人: Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人: Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号: A61K31/5377 , C07D413/14 , A61K31/538 , A61P29/00 , A61P35/00 , A61P11/00 , A61P37/08 , A61P37/00 , A61P9/00
CPC分类号: C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要: Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译: 磷脂酰肌醇(PI)3-激酶抑制剂化合物,其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性,蛋白质丝氨酸/苏氨酸激酶和磷脂激酶(包括增殖性疾病)的疾病中的用途, 炎性和阻塞性气道疾病,过敏性疾病,自身免疫性疾病和心血管疾病。
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