公开(公告)号：US20240117030A1

公开(公告)日：2024-04-11

申请号：US18175796

申请日：2023-02-28

Applicant: Pfizer Inc.

Inventor： Rita Diane AGOSTINELLI ,  James Reasoner APGAR ,  Eric Matthew BENNETT ,  Laird BLOOM ,  Ting CHEN ,  Aaron Michael D'ANTONA ,  Arnab DE ,  Fang JIN ,  Marion Teresa KASAIAN ,  Matthew Allister LAMBERT ,  Kimberly Ann MARQUETTE ,  Virginie MCMANUS ,  Jessica Haewon MIN DEBARTOLO ,  Nicole Melissa PICHE-NICHOLAS ,  Richard Thomas SHELDON ,  Lioudmila TCHISTIAKOVA ,  Alexander Michael Shuford BARRON ,  Richard Lee GIESECK, III ,  Xiaotian ZHONG

IPC: C07K16/24 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07K16/247 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.