公开(公告)号：US20220202923A1

公开(公告)日：2022-06-30

申请号：US17554424

申请日：2021-12-17

Applicant: Pfizer Inc.

Inventor： Ye Che ,  Laurent Oliver Chorro ,  Robert George Konrad Donald ,  Matthew Curtis Griffor ,  Natalie Clare Silmon de Monerri

IPC: A61K39/108 ,  C07K14/245 ,  C07K16/12

Abstract: This disclosure relates to the design of E. coli mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, and uses thereof.

公开(公告)号：US20250000960A1

公开(公告)日：2025-01-02

申请号：US18739401

申请日：2024-06-11

Applicant: Pfizer Inc.

Inventor： Eric Matthew Bennett ,  Robert George Konrad Donald ,  Laura Lin Lohse ,  Natalie Clare Silmon de Monerri

IPC: A61K39/108 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00 ,  A61P31/04 ,  C07K14/245 ,  C12N15/11

Abstract: The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.