公开(公告)号：US20240299587A1

公开(公告)日：2024-09-12

申请号：US18277425

申请日：2022-02-21

Applicant: Pfizer Inc.

Inventor： Xiaoyuan Sherry Chi ,  Philip Ralph Dormitzer ,  Weifeng Liu ,  Yuhang Liu

IPC: A61K49/00 ,  A61K38/16 ,  A61P31/22

CPC classification number: A61K49/0004 ,  A61K38/162 ,  A61P31/22

Abstract: The present invention relates to a method for identifying a candidate therapeutic for a disease caused by infection with a human cytomegalovirus (HCMV) having a glycoprotein B (gB) polypeptide, comprising contacting the HCMV gB polypeptide comprising a druggable region with a compound, wherein binding of said compound indicates a candidate therapeutic. The present invention also relates to candidate therapeutics comprising modulators and inhibitors of HCMV activity and pharmaceutical compositions comprising said modulators and inhibitors and methods of use thereof.