公开(公告)号：US20100311642A1

公开(公告)日：2010-12-09

申请号：US12680452

申请日：2008-09-25

申请人： Pierre J-m.Riviere ,  Sudar Alagarsamy ,  Claudio Daniel Schteingart ,  Regent Laporte

发明人： Pierre J-m.Riviere ,  Sudar Alagarsamy ,  Claudio Daniel Schteingart ,  Regent Laporte

IPC分类号： A61K38/11 ,  A61K31/55 ,  A61K31/5377 ,  A61P7/00 ,  A61P11/00

CPC分类号： A61K31/55 ,  A61K38/095 ,  A61K2300/00

摘要： The combination of vasopressin V2 receptor antagonists and vasopressin receptor agonists (selective or non-selective) is described, including pharmaceutical compositions, including kits, for administering, and methods and uses of such a combination, e.g. for treatment of critical care diseases and conditions requiring control of arterial blood pressure or for treatment of hypotension. Also described is the use of a combination of a vasopressin V2 receptor antagonist with a vasopressin receptor agonist for the manufacture of a medicament for treatment of critical care conditions requiring control of arterial blood pressure, vascular leak and/or vasodilation, methods for treatment of a critical care condition in a mammal needing control of arterial blood pressure, vascular leak and/or vasodilation, the method comprising administering to the mammal a therapeutically effective amount of a vasopressin V2 receptor antagonist and administering to the mammal a therapeutically effective amount of a vasopressin receptor agonist, and a kit comprising a therapeutically effective amount of one or more vasopressin V2 receptor antagonists in a pharmaceutically acceptable composition and a therapeutically effective amount one or more vasopressin receptor agonists in a pharmaceutically acceptable composition.

摘要翻译： 描述了加压素V2受体拮抗剂和加压素受体激动剂（选择性或非选择性）的组合，包括药物组合物，包括用于给予这些组合的方法和用途，包括试剂盒。 用于治疗重症监护病症和需要控制动脉血压或治疗低血压的病症。 还描述了使用加压素V2受体拮抗剂与加压素受体激动剂的组合来制备用于治疗需要控制动脉血压，血管渗漏和/或血管舒张的关键护理条件的药物的治疗方法 需要控制动脉血压，血管渗漏和/或血管舒张的哺乳动物中的重要护理条件，所述方法包括向哺乳动物施用治疗有效量的加压素V2受体拮抗剂，并向哺乳动物施用治疗有效量的血管加压素受体 激动剂和试剂盒，其包含药学上可接受的组合物中治疗有效量的一种或多种加压素V2受体拮抗剂和治疗有效量的药学上可接受的组合物中的一种或多种血管加压素受体激动剂。