利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.054 秒)

    Use of Pyrimidylaminobenzamide Derivatives for the Treatment of Fibrosis
    5.
    发明申请
    Use of Pyrimidylaminobenzamide Derivatives for the Treatment of Fibrosis 审中-公开
    使用嘧啶基氨基苯甲酰胺衍生物治疗纤维化

    公开(公告)号：US20130267549A1

    公开(公告)日：2013-10-10

    申请号：US13911127

    申请日：2013-06-06

    申请人： Elisabeth BUCHDUNGER ,  Paul W. MANLEY

    发明人： Elisabeth BUCHDUNGER ,  Paul W. MANLEY

    IPC分类号： A61K31/506 ,  A61K31/41 ,  A61K45/06

    CPC分类号： A61K31/506 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to the use of a pyrimidylaminobenzamides of formula I wherein the radicals have the meanings as defined herein, or of a pharmaceutically acceptable salt thereof for the manufacture of pharmaceutical compositions for use in the treatment of fibrosis, to the use of a pyrimidylaminobenzamides of formula I or pharmaceutically acceptable salt thereof in the treatment of fibrosis, to a method of treating warm-blooded animals including humans suffering from fibrosis by administering to a said animal in need of such treatment an effective dose of a pyrimidyl-aminobenzamide of formula I or a pharmaceutically acceptable salt thereof, and to combinations comprising (a) at least one pyrimidylaminobenzamides of formula I as and (b) at least one compound selected form AT1-receptor antagonists and ACE inhibitors and the use of such combinations in the treatment of fibrosis, in particular hepatic fibrosis.

    摘要翻译： 本发明涉及式I的嘧啶基氨基苯甲酰胺的用途，其中基团具有如本文所定义的含义或其药学上可接受的盐在制备用于治疗纤维化的药物组合物中的用途，使用嘧啶基氨基苯甲酰胺 式I或其药学上可接受的盐在治疗纤维化中的用途，涉及一种通过向需要这种治疗的所述动物施用有效剂量的式I的嘧啶基 - 氨基苯甲酰胺或其制备方法来治疗包括患有纤维化的人的温血动物的方法，或 以及包含（a）至少一种式I的嘧啶基氨基苯甲酰胺和（b）至少一种选自AT1受体拮抗剂和ACE抑制剂的化合物的组合的组合，以及这些组合在治疗纤维化中的用途， 特别是肝纤维化。