公开(公告)号：US20230321218A1

公开(公告)日：2023-10-12

申请号：US17995733

申请日：2021-04-07

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Jonathan M. GERSHONI

IPC: A61K39/215 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61P37/04 ,  A61K2039/70

Abstract: The present invention relates to vaccines and therapeutic compositions targeted at coronaviruses, specifically, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS CoV2). More specifically, the invention provides reconstituted Receptor Binding Motif (RBM) of a Spike protein of the SARS CoV2, Receptor Binding domains (RBDs), and spike proteins comprising the reconstituted RBMs or τ-linkers, compositions, vaccines, therapeutic and diagnostic methods and uses thereof.