公开(公告)号：US20210244828A1

公开(公告)日：2021-08-12

申请号：US17054938

申请日：2019-05-14

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Eran PERLSON ,  Roy MAIMON ,  Oded BEHAR

IPC: A61K48/00 ,  C12N15/113 ,  A61K9/00 ,  A61P25/28

Abstract: The present invention relates to methods for treating motor neuron diseases and neuromuscular junction abnormalities. Particularly, the methods comprise increasing miRNA126-5p expression in skeletal muscle cells and/or motor neurons, and/or inhibiting miRNA126-5p expression in glial cells, thereby spatially up-regulating and/or down-regulating miRNA126-5p levels, and thus treating amyotrophic lateral sclerosis.