公开(公告)号：US20140186829A1

公开(公告)日：2014-07-03

申请号：US14008631

申请日：2012-04-02

申请人： Remy Burcelin ,  Jacques Amar ,  Beverly Balkau

发明人： Remy Burcelin ,  Jacques Amar ,  Beverly Balkau

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689

摘要： The present invention relates to an in vitro method, for predicting a risk of onset of type 2 diabetes in a subject, which method comprises the steps of: a) measuring the concentration of bacterial 16S rDNA in a biological sample of said subject; and b) comparing said measured concentration of bacterial 16S rDNA to a threshold level; wherein a measured concentration of bacterial 16S rDNA higher than the threshold level is indicative of an increased risk of onset of type 2 diabetes in the subject, and a measured concentration of bacterial 16S rDNA lower than the threshold level is indicative of a decreased risk of onset of type 2 diabetes in the subject.

摘要翻译： 本发明涉及用于预测受试者的2型糖尿病发病风险的体外方法，该方法包括以下步骤：a）测量所述受试者生物样品中细菌16S rDNA的浓度; 和b）将所述测量的细菌16S rDNA浓度与阈值水平进行比较; 其中测量的高于阈值水平的细菌16S rDNA的浓度指示受试者中2型糖尿病发病的风险增加，并且测定的低于阈值水平的细菌16S rDNA的浓度表明发病风险降低 的2型糖尿病。