公开(公告)号：US20240350505A1

公开(公告)日：2024-10-24

申请号：US18537061

申请日：2023-12-12

Applicant: Repare Therapeutics Inc.

Inventor： Michal Zimmermann ,  Anne Roulston ,  Maria Koehler

IPC: A61K31/5377 ,  A61K9/00 ,  A61K31/454 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/541 ,  A61K31/55 ,  A61P35/00

CPC classification number: A61K31/5377 ,  A61K9/0053 ,  A61K31/454 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/541 ,  A61K31/55 ,  A61P35/00

Abstract: Disclosed are methods of treating a cancer in a subject using an ATR inhibitor and PARP inhibitor. wherein the cancer has been previously identified as a cancer having a loss of function of ATM, BRCA2, RNAse H2A, RNAse H2B, CDK12, or a combination thereof, or as an ALT+ cancer. Also disclosed are methods of inducing cell death in an aberrant cancer cell having a loss of function of ATM, BRCA2, RNAse H2A, RNAse H2B, CDK12, or a combination thereof, or an ALT+ cancer cell, by contacting the cell with an effective amount of an ATR inhibitor and PARP inhibitor.