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8 条记录 (耗时 0.039 秒)

    Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
    3.
    发明授权
    Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings 失效
    具有C-C键与4-8元杂环的苯基恶唑烷酮

    公开(公告)号：US06313307B1

    公开(公告)日：2001-11-06

    申请号：US09518788

    申请日：2000-03-03

    申请人： Michael Dalton Ennis ,  Robert Louis Hoffman ,  Douglas K. Hutchinson ,  David John Anderson ,  Toni-Jo Poel ,  Richard Charles Thomas

    发明人： Michael Dalton Ennis ,  Robert Louis Hoffman ,  Douglas K. Hutchinson ,  David John Anderson ,  Toni-Jo Poel ,  Richard Charles Thomas

    IPC分类号： C07D26304

    CPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/14

    摘要： A process for preparing a compound of the formula I: or pharmaceutical acceptable salts thereof wherein X is —NR1—, —S(O)g—, or —O—; R1 is —H, C1-6 alkyl optionally substituted with one or more —OH, —CN, or halo, or R1 is —(CH2)h-aryl, —COR1-1, —COOR1-2, —CO—(CH2)h—COR1-1, C1-6 alkyl sulfonyl, —SO2—(CH2)h-aryl, or —(CO)i-Het; R2 is —H, C1-6 alkyl, —(CH2)h-aryl, or halo; R3 and R4 are the same or different and are —H or halo; R6 is —H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.

    摘要翻译： 制备式I化合物或其药学上可接受的盐的方法，其中X为-NR 1 - ， - S（O）g - 或-O-; R 1是-H，任选地被一个或多个-OH，-CN或卤素取代的C 1-6烷基，或者R 1是 - （CH 2）h - 芳基，-COR 1 -1，-COOR 1-2，-CO-（CH 2 ）h-COR1-1，C 1-6烷基磺酰基，-SO 2 - （CH 2）h - 芳基或 - （CO）i-Het; R2是-H，C1-6烷基， - （CH2）h-芳基或卤素; R3和R4相同或不同，为-H或卤素; R6是-H，任选地被一个或多个卤素，C 2-3-12环烷基，C 1-6烷氧基取代的C 1-12烷基。 这些化合物是有用的抗微生物剂。

    Oxazolidinone antibacterial agent with tricyclic substituents
    8.
    发明授权
    Oxazolidinone antibacterial agent with tricyclic substituents 失效
    恶唑烷酮抗菌剂，具有三环取代基

    公开(公告)号：US5955460A

    公开(公告)日：1999-09-21

    申请号：US250382

    申请日：1999-02-15

    申请人： Richard Charles Thomas

    发明人： Richard Charles Thomas

    IPC分类号： A61K31/00 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5383 ,  A61K31/54 ,  A61P31/00 ,  A61P31/04 ,  C07D498/04 ,  C07D513/04

    CPC分类号： C07D498/04

    摘要： This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR.sub.1, CR.sub.2 R.sub.3, O, S, SO, or SO.sub.2 ; and Z is NR.sub.4, S, SO, SO.sub.2 or O. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.

    摘要翻译： 本发明提供由化学式（I）表示的新型恶唑烷酮衍生物或其药学上可接受的盐：其中X为NR 1，CR 2 R 3，O，S，SO或SO 2; Z是NR4，S，SO，SO2或O.这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌，如多重耐药性葡萄球菌和链球菌，以及厌氧生物 例如细菌和梭菌，以及耐酸生物如结核分枝杆菌和鸟分枝杆菌。