公开(公告)号：US5204352A

公开(公告)日：1993-04-20

申请号：US102445

申请日：1987-09-29

申请人： Richard J. Sundberg ,  Daniel J. Dahlhausen ,  Govindarajan Manikumar ,  Babu J. Mavunkel ,  Hikmat A. Musallam ,  Atanu Biswas ,  Srinivasan Varadarajan

发明人： Richard J. Sundberg ,  Daniel J. Dahlhausen ,  Govindarajan Manikumar ,  Babu J. Mavunkel ,  Hikmat A. Musallam ,  Atanu Biswas ,  Srinivasan Varadarajan

IPC分类号： C07D213/53 ,  C07D233/54 ,  C07D471/04 ,  C07D513/04

CPC分类号： C07D213/53 ,  C07D233/64 ,  C07D471/04 ,  C07D513/04

摘要： Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.

摘要翻译： 提供新的化合物，其具有高水平的抗寄生虫活性，特别是针对锥虫属的寄生虫。 该化合物包括芳基取代的季芳香盐，其包括带正电荷的咪唑鎓或其它杂环，连接基，苯环和极性官能团。 极性官能团优选为anyl腙或杂环腙。 还提供了一种治疗与锥虫属寄生虫相关的疾病的方法，其包括向受感染的动物或人施用有效量的本发明化合物。