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公开(公告)号:US08143414B2
公开(公告)日:2012-03-27
申请号:US12755631
申请日:2010-04-07
IPC分类号: C07D513/14 , A61K31/426 , A61K31/428 , A61K31/429
CPC分类号: C07D513/04
摘要: This disclosure concerns novel compounds of Formula (I) or Formula (II) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译: 本公开涉及如本说明书中定义的式(I)或式(II)的新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂,特别是抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能。 因此,本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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公开(公告)号:US20110098327A1
公开(公告)日:2011-04-28
申请号:US12755631
申请日:2010-04-07
IPC分类号: A61K31/429 , C07D513/04 , C07D498/04 , C07D487/04 , A61P31/14
CPC分类号: C07D513/04
摘要: This disclosure concerns novel compounds of Formula (I) or Formula (II) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译: 本公开涉及如本说明书中定义的式(I)或式(II)的新化合物和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂,特别是抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能。 因此,本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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公开(公告)号:US20130012540A1
公开(公告)日:2013-01-10
申请号:US13611708
申请日:2012-09-12
申请人: Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
发明人: Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
IPC分类号: A61K31/4178 , C07D417/14 , A61K31/427 , C07D413/14 , A61P31/14 , C07D403/14 , C07D401/14 , A61K31/4545 , C07D407/14 , C07D409/14 , A61K31/422
CPC分类号: C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
摘要: This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译: 本公开涉及式(I)的新化合物或说明书中定义的和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂,特别是抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能。 因此,本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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公开(公告)号:US20110281910A1
公开(公告)日:2011-11-17
申请号:US12942183
申请日:2010-11-09
申请人: Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
发明人: Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
IPC分类号: A61K31/4178 , C07D417/14 , C07D413/14 , C07D403/14 , A61P31/14 , C07D407/14 , A61K31/427 , A61K31/422 , A61K31/4545 , C07D409/14 , C07D401/14
CPC分类号: C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
摘要: This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译: 本公开涉及式(I)的新化合物或说明书中定义的和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂,特别是抑制由丙型肝炎病毒(HCV)编码的NS5A蛋白的功能。 因此,本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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公开(公告)号:US20080299075A1
公开(公告)日:2008-12-04
申请号:US12029680
申请日:2008-02-12
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号: C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US20080044379A1
公开(公告)日:2008-02-21
申请号:US11835485
申请日:2007-08-08
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号: C07D401/14 , C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20080188481A1
公开(公告)日:2008-08-07
申请号:US12015767
申请日:2008-01-17
申请人: Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
发明人: Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
IPC分类号: A61K31/497 , A61K31/4523 , A61K31/506 , A61P31/18 , A61K31/437
CPC分类号: C07D401/06 , C07D413/14 , C07D471/04
摘要: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is
摘要翻译: 本发明提供具有药物和生物影响性质的化合物,其药物组合物和使用方法。 特别地,本发明涉及具有独特抗病毒活性的新的哌啶-4-链烯基衍生物。 更具体地,本发明涉及可用于治疗HIV和AIDS的化合物。 用于通式I的本发明化合物:其中:Z是Q选自:-W-是
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公开(公告)号:US08288562B2
公开(公告)日:2012-10-16
申请号:US12786703
申请日:2010-05-25
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: C07D233/02 , A01N43/50
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20100233120A1
公开(公告)日:2010-09-16
申请号:US12786703
申请日:2010-05-25
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , C07D403/14 , A61K31/501 , A61K31/506 , A61K31/4439 , C07D401/14 , A61K38/21 , A61K31/7056 , A61K31/713 , A61K31/437 , A61P31/22
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20090068140A1
公开(公告)日:2009-03-12
申请号:US12030232
申请日:2008-02-13
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K31/506 , A61K38/16 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61P31/12
CPC分类号: A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物以及使用这些化合物治疗HCV感染的方法。
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