公开(公告)号：US5256676A

公开(公告)日：1993-10-26

申请号：US918080

申请日：1992-07-24

申请人： Robert C. Hider ,  Timothy E. A. Peto ,  Surinder Singh ,  Susan Whitehead

发明人： Robert C. Hider ,  Timothy E. A. Peto ,  Surinder Singh ,  Susan Whitehead

IPC分类号： A61K31/14 ,  A61K31/44 ,  C07D213/69 ,  C07D211/74

CPC分类号： C07D213/69 ,  A61K31/14 ,  A61K31/44

摘要： 3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a C.sub.3 or C.sub.4 hydroxyalkyl group in which the hydroxy group is terminally substituted on the alkyl group, R.sub.2 is methyl or ethyl and R.sub.3 and R.sub.4 are each separately hydrogen, methyl or ethyl but with the proviso that the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than six, the compound optionally being in the form of a physiologically acceptable salt and/or pro-drug thereof, are of value for the treatment of conditions caused by iron dependent parasites, particularly malaria.

摘要翻译： 式（I）的3-羟基吡啶-4-酮其中R1是其中羟基被烷基末端取代的C3或C4羟烷基，R2是甲基或乙基，R3和R4 分别为氢，甲基或乙基，但条件是R1至R4中的碳原子总数不超过6，任选呈生理上可接受的盐和/或其前体形式的化合物为 治疗由铁依赖寄生虫，特别是疟疾引起的病症的价值。