Process for preparing iodothyronines and iodothyroacetic acids by
electrochemical reduction at controlled potential
    3.
    发明授权
    Process for preparing iodothyronines and iodothyroacetic acids by electrochemical reduction at controlled potential 失效
    通过电化学还原在受控电位制备碘代甲状腺氨酸和碘代乙酸的方法

    公开(公告)号:US4490221A

    公开(公告)日:1984-12-25

    申请号:US489536

    申请日:1983-04-28

    摘要: The invention relates to a process for preparing tri-iodo-, di-iodo- and mono-iodothyronines and tri-iodo, di-iodo and mono-iodothyroacetic acids, respectively from thyronine, triiodo or diiodothyro- nine and tetra-, tri- or diiodothyroacetic acid, by electrochemical reduction at controlled potential, in an aqueous medium rendered alkaline by the addition in particular of a tetraalkylammonium hydroxide, whereby either the iodine in 5 position or the iodine in 3 position is selectively reduced, depending on the potential at which operation is carried out, and which is determined previously by plotting a polarograph of the starting substance.

    摘要翻译: 本发明涉及分别由甲基,三碘或二碘甲基和四碘,三碘代三碘代三碘,二碘和一碘碘甲基三碘, 或二碘甲基乙酸,通过在受控电位下的电化学还原,在通过添加特别是四烷基氢氧化铵使碱性化的水性介质中,其中5位的碘或3位的碘被选择性地还原,这取决于其中的 进行操作,其通过绘制起始物质的极谱仪先前确定。