公开(公告)号：US20140363835A1

公开(公告)日：2014-12-11

申请号：US14466264

申请日：2014-08-22

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Gabriele Chemnitius ,  Otto Gaa ,  Thomas Nagel ,  Karl Recht

IPC: C12Q1/32

CPC classification number: C12Q1/32 ,  G01N2333/902

Abstract: Dry reagent compositions are disclosed for maintaining and preserving enzymatic activity. Also disclosed are test elements incorporating the same and methods of making and using the same for determining the presence or amount of an analyte in a body fluid sample. The dry reagent compositions can include components such as a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof.

Abstract translation: 公开了用于维持和保存酶活性的干试剂组合物。 还公开了包含其的测试元件以及制造和使用该测试元件以确定体液样品中分析物的存在或量的方法。 干试剂组合物可以包括组分，例如脱氢酶，氧化还原辅因子，能够在氧化还原当量存在下引发指示剂的光学性质的至少一种光学变化的试剂，指示剂试剂和至少一种相容性 溶质是ectoine或其衍生物。