公开(公告)号：US20220155269A1

公开(公告)日：2022-05-19

申请号：US17649801

申请日：2022-02-03

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Galina Babitzki ,  Ruediger Laubender ,  Julian Michely ,  Andreas Reichert ,  Kirill Tarasov

IPC: G01N30/86 ,  G01N30/72

Abstract: A computer implemented method for automatic peak integration of at least one chromatogram of at least one sample. The method comprises retrieving at least one chromatogram of the chemical related substance and at least one chromatogram of the analyte; evaluating the chromatogram of the chemical related substance, wherein the evaluating comprises determining at least one initial value for analyte retention time by determining retention time of the chemical related substance and adding the retention time of the chemical related substance with a pre-determined or pre-defined constant offset and/or multiplying the retention time of the chemical related substance with a pre-determined or pre-defined constant factor; evaluating the chromatogram of the analyte, wherein the evaluating comprises at least one position determining step; and at least one peak integration step, wherein analyte peak area and analyte peak shape are determined by applying at least one fitting analysis to the chromatogram of the analyte.