公开(公告)号：US20230168230A1

公开(公告)日：2023-06-01

申请号：US18096477

申请日：2023-01-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Daniel Intelmann ,  Katrin Koenig ,  Patrick Neiens ,  Tibor Toth

IPC: G01N30/88 ,  G01N30/86

CPC classification number: G01N30/88 ,  G01N30/8658 ,  G01N2030/889

Abstract: The present invention relates to a method for operating a chromatography column comprising (a) providing a first value of a lifetime (first lifetime value) of said chromatography column; (b) performing a chromatographic separation of a sample on said chromatography column; (c) providing a value of a weighted aging factor determined based on at least one aging parameter selected from sample type, sample dilution, and sample volume; and (d) determining a second value of said lifetime (second lifetime value) of said chromatography column based on said first lifetime value and said weighted aging factor. The present invention also relates to further methods, databases, devices, and uses related thereto.