公开(公告)号：US20240248069A1

公开(公告)日：2024-07-25

申请号：US18566548

申请日：2022-05-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Adrian Sievers-Engler ,  Tibor Toth

IPC: G01N30/72 ,  G01N30/62

CPC classification number: G01N30/7266 ,  G01N2030/621

Abstract: An analyzer system (110) is disclosed. The analyzer system (110) comprises:



at least one mass spectrometry device (112) having at least one electrospray ion source nozzle (114);
at least one liquid supply (116), wherein the liquid supply (116) is configured for providing at least one liquid having at least one analyte;
at least one gas supply (118), wherein the gas supply (118) is configured for providing at least one gas; and
at least one dopand gas supply (120), wherein the dopand gas supply (120) is configured for providing at least one chemical dopand gas having at least one chemical dopand (122) to the analyte provided by the liquid supply (116);

wherein the liquid supply (116) and the gas supply (118) are coupled to the mass spectrometry device (112) via the electrospray ion source nozzle (114), wherein the dopand gas supply (120) is connected to the gas supply (118).

公开(公告)号：US20230168230A1

公开(公告)日：2023-06-01

申请号：US18096477

申请日：2023-01-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Daniel Intelmann ,  Katrin Koenig ,  Patrick Neiens ,  Tibor Toth

IPC: G01N30/88 ,  G01N30/86

CPC classification number: G01N30/88 ,  G01N30/8658 ,  G01N2030/889

Abstract: The present invention relates to a method for operating a chromatography column comprising (a) providing a first value of a lifetime (first lifetime value) of said chromatography column; (b) performing a chromatographic separation of a sample on said chromatography column; (c) providing a value of a weighted aging factor determined based on at least one aging parameter selected from sample type, sample dilution, and sample volume; and (d) determining a second value of said lifetime (second lifetime value) of said chromatography column based on said first lifetime value and said weighted aging factor. The present invention also relates to further methods, databases, devices, and uses related thereto.

公开(公告)号：US20230037141A1

公开(公告)日：2023-02-02

申请号：US17965290

申请日：2022-10-13

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC. ,  HITACHI HIGH-TECH CORPORATION

Inventor： Stefan Quint ,  Tibor Toth ,  Aart Pieter Van Doorn ,  Yuichiro Hashimoto

IPC: G01N30/46 ,  G01N30/72

Abstract: The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.