专利检索 ap:("Ronan O'Hagan" OR "H. Heidi Okamura" OR "Alisa C. Bell" OR "Jeanine Lorusso") AND inv:"Alisa C. Bell" 第 1 页

1.

发明授权
Identifying cancers sensitive to treatment with inhibitors of notch signaling 有权
标题翻译：鉴定对使用缺口信号抑制剂治疗敏感的癌症

公开(公告)号：US07544476B1

公开(公告)日：2009-06-09

申请号：US12360790

申请日：2009-01-27

申请人： Ronan O'Hagan , H. Heidi Okamura , Alisa C. Bell , Jeanine Lorusso

发明人： Ronan O'Hagan , H. Heidi Okamura , Alisa C. Bell , Jeanine Lorusso

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158

摘要： The disclosure provides a method for identifying cancer tissue sensitive to treatment with an inhibitor of Notch receptor activation. The method comprises determining the level of HeyL gene expression in a sample derived from the cancer tissue, wherein an elevated level of HeyL gene expression alone in the sample indicates sensitivity to the cancer tissue to treatment with an inhibitor of Notch receptor activation.

摘要翻译： 本公开提供了用于鉴定对用Notch受体激活抑制剂治疗敏感的癌组织的方法。该方法包括确定衍生自癌组织的样品中HeyL基因表达的水平，其中样品中单独提高的HeyL基因表达水平表示对癌组织的敏感性，以用Notch受体激活抑制剂进行治疗。