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公开(公告)号:US20140343029A1
公开(公告)日:2014-11-20
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/506 , C07D413/14 , C07D491/107 , C07D409/14 , C07D417/14 , A61K31/5377 , A61K31/4545
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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公开(公告)号:US09145392B2
公开(公告)日:2015-09-29
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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3.
公开(公告)号:US20150126484A1
公开(公告)日:2015-05-07
申请号:US14236405
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Yufang Xiao , Hui Qiu , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Yufang Xiao , Hui Qiu , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
IPC分类号: C07D417/12 , A61K31/506 , C07D403/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D401/14 , C07D413/14 , C07D405/12 , C07D239/48 , C07D403/12
CPC分类号: A61K31/506 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I)的新型杂环胺化合物及其制备和用于治疗过度增殖性疾病如癌症的用途。
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4.
公开(公告)号:US09321760B2
公开(公告)日:2016-04-26
申请号:US14236405
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Yufang Xiao , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Yufang Xiao , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
IPC分类号: A61K31/506 , C07D417/12 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D239/48 , C07D413/04 , C07D417/14 , C07D405/12
CPC分类号: A61K31/506 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I)的新型杂环胺化合物及其制备和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号:US08735584B2
公开(公告)日:2014-05-27
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: C07D471/04 , C07D471/06
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US20110053906A1
公开(公告)日:2011-03-03
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: A61K31/4745 , C07D471/04 , A61K31/5377 , A61K31/496 , A61K31/536 , A61P35/00
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US20140107156A1
公开(公告)日:2014-04-17
申请号:US14105974
申请日:2013-12-13
申请人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号: C07D215/04 , A61K31/47
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08637532B2
公开(公告)日:2014-01-28
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20130217709A1
公开(公告)日:2013-08-22
申请号:US13810860
申请日:2011-07-28
申请人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号: C07D403/12 , A61K31/4709 , C07D403/14 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/517 , A61K45/06
CPC分类号: C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I),式(II)和式(III)的新型环胺氮杂环甲酰胺,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US09586938B2
公开(公告)日:2017-03-07
申请号:US13810860
申请日:2011-07-28
申请人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号: A01N43/54 , C07D239/42 , C07D401/04 , A01N43/42 , A61K31/47 , C07D403/12 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D403/14
CPC分类号: C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I),式(II)和式(III)的新型环胺氮杂环甲酰胺,其用于治疗过度增殖性疾病如癌症的制备和用途。
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