公开(公告)号：US20230049557A1

公开(公告)日：2023-02-16

申请号：US17782117

申请日：2020-12-02

申请人： SAMJIN PHARMACEUTICAL CO., LTD. ,  INCHEON NATIONAL UNIVERSITY RESEARCH & BUSINESS FOUNDATION ,  BAMICHEM CO., LTD.

发明人： Min Hyo KI ,  Ho Seok KWON ,  Young Hun LEE ,  Eunsun SONG ,  Yong Bin PARK ,  Kug Hwa LEE ,  Hyoung Min CHO ,  Soon Kil AHN ,  Sung Pyo HONG ,  Sung Hye KIM

IPC分类号： C07D239/48 ,  C07D401/12 ,  A61P35/00

摘要： The present invention provides novel adamantane derivatives as inhibitors of a focal adhesion kinase, pharmaceutically acceptable salts thereof, stereoisomers thereof, hydrates or solvates thereof, and a pharmaceutical composition comprising same.

公开(公告)号：US20190300531A1

公开(公告)日：2019-10-03

申请号：US16074950

申请日：2017-01-11

申请人： SAMJIN PHARMACEUTICAL CO., LTD. ,  INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION ,  BAMICHEM CO., LTD.

发明人： Eui Hwan CHO ,  Hee Jong SHIN ,  Min Hyo KI ,  Ho Seok KWON ,  Jae Woong LEE ,  Jeong Ho JOO ,  Keun Kuk LEE ,  Jong Min KIM ,  Yong Bin PARK ,  Sung Hyun KANG ,  Hyoung Min CHO ,  Hyun Tae KIM ,  Soon Kil AHN ,  Sung Pyo HONG ,  Sung Hye KIM

IPC分类号： C07D473/00 ,  C07D487/04 ,  A61P35/00

摘要： The present invention provides a novel pyridine derivative, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient. The pyridine derivative according to the present invention inhibits Raf kinase (B-Raf, Raf-1, or B-RafV600E) and a vascular endothelial growth factor receptor (VEGFR2) involved in angiogenesis, and thus, can be favorably used for the prevention or treatment of melanoma, colorectal cancer, prostate cancer, thyroid cancer, lung cancer, pancreatic cancer, ovarian cancer, or the like, which is induced by RAS mutation.