公开(公告)号：US20170320865A1

公开(公告)日：2017-11-09

申请号：US15523247

申请日：2015-10-27

申请人： SCOTT D. KUDUK ,  NIGEL LIVERTON ,  YUNFU LUO

发明人： SCOTT D. KUDUK ,  NIGEL LIVERTON ,  YUNFU LUO

IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D263/32

CPC分类号： C07D413/14 ,  C07D263/32 ,  C07D413/12

摘要： The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

公开(公告)号：US20170319560A1

公开(公告)日：2017-11-09

申请号：US15523256

申请日：2015-10-27

申请人： NIGEL LIVERTON ,  SCOTT D. KUDUK ,  DOUGLAS BESHORE ,  YUNFU LUO ,  NA MENG

发明人： NIGEL LIVERTON ,  SCOTT D. KUDUK ,  DOUGLAS BESHORE ,  YUNFU LUO ,  NA MENG

IPC分类号： A61K31/445 ,  C07D409/14 ,  C07D401/14 ,  C07D413/14 ,  C07D401/04

CPC分类号： A61K31/445 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04

摘要： The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the pyrazole, triazole, and tetrazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.