公开(公告)号：US20180147594A1

公开(公告)日：2018-05-31

申请号：US15571768

申请日：2016-03-07

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  PURETECK CO., LTD.

Inventor： Jeong Woo Kim ,  Jeong Yang Kim ,  Yun Jaie Choi

IPC: B05B17/06 ,  B05B1/02 ,  F24F6/12 ,  F24F13/08 ,  F24F13/20

CPC classification number: B05B17/0607 ,  B05B1/02 ,  B05B7/0012 ,  B05B17/0615 ,  B05B17/0676 ,  F24F6/12 ,  F24F11/0008 ,  F24F13/08 ,  F24F13/20 ,  F24F2006/008 ,  F24F2013/205

Abstract: The present invention relates to a supraparticle atomizing device and, more specifically, to a supraparticle atomizing device having an inner plate provided at the upper part of an ultrasonic vibrator inside a housing and having a circulation passage formed at the circumference of the inner plate of the inside of the housing by using the rapid flow rate of the air to be ventilated to the inside of the housing through a blower, and thus only liquid microparticles generated at the lower region of the inner plate by the ultrasonic vibrator are pulled up to the upper region thereof, thereby allowing the liquid microparticles to be atomized through an atomizing hole and allowing the liquid microparticles to be rapidly diffused into the air with rapid ventilation air.

公开(公告)号：US20180200373A1

公开(公告)日：2018-07-19

申请号：US15742792

申请日：2016-05-13

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Chong Su Cho ,  Yun Jaie Choi ,  Sang Kee Kang ,  Bijay Singh ,  Maharjan Sushila

IPC: A61K47/38 ,  A61K39/02

CPC classification number: A61K47/38 ,  A61K9/1652 ,  A61K9/50 ,  A61K9/5042 ,  A61K39/02 ,  A61K39/0225 ,  A61K2039/542 ,  A61K2039/55583 ,  A61K2039/6093

Abstract: The present disclosure relates to a thiolated hydroxypropyl methylcellulose phthalate (T-HPMCP) drug delivery vehicle which is pH responsive and is loaded with either a protein drug or an antigen, to T-HPMCP microparticles, and to a production method for an ileum-specific, pH responsive, T-HPMCP drug delivery vehicle, the method including a step of loading a protein drug or an antigen onto the T-HPMCP microparticles. The T-HPMCP microparticles of the present disclosure are soluble in chlorinated methane because of the introduction of the thiol group, while a T-HPMCP drug delivery vehicle produced from the particles can efficiently effect in vivo delivery of the protein drug or antigen which is loaded thereon, since said vehicle is pH responsive such that the in vivo residence time is extended and the vehicle can act specifically on the ileum.