公开(公告)号：US10399978B2

公开(公告)日：2019-09-03

申请号：US16313149

申请日：2016-09-02

Applicant: SHANDONG UNIVERSITY

Inventor： Xinyong Liu ,  Qing Meng ,  Peng Zhan ,  Zengjun Fang ,  Tong Zhao ,  Zhuosen Sun ,  Xiukun Sun

IPC: C07D471/04 ,  A61P19/06

Abstract: It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.

公开(公告)号：US20200031844A1

公开(公告)日：2020-01-30

申请号：US15735135

申请日：2016-07-12

Applicant: SHANDONG UNIVERSITY

Inventor： Xinyong Liu ,  Heng Zhang ,  Peng Zhan ,  Zhongxia Zhou ,  Dongwei Kang

IPC: C07D495/04 ,  A61P31/18

Abstract: The invention relates the tetrahydrothiopyranopyrimidine derivatives, the preparation, and the use thereof. The invention contained tetrahydrothiopyranopyrimidine derivatives, and pharmaceutical acceptable salt and prodrug with the formula I or II. Also described here are preparation of tetrahydrothiopyranopyrimidine derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for HIV.

公开(公告)号：US10590145B2

公开(公告)日：2020-03-17

申请号：US15735135

申请日：2016-07-12

Applicant: SHANDONG UNIVERSITY

Inventor： Xinyong Liu ,  Heng Zhang ,  Peng Zhan ,  Zhongxia Zhou ,  Dongwei Kang

IPC: C07D495/06 ,  A61K31/519 ,  C07D495/04 ,  A61P31/18

Abstract: The invention relates the tetrahydrothiopyranopyrimidine derivatives, the preparation, and the use thereof. The invention contained tetrahydrothiopyranopyrimidine derivatives, and pharmaceutical acceptable salt and prodrug with the formula I or II. Also described here are preparation of tetrahydrothiopyranopyrimidine derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for HIV.