公开(公告)号：US20220211920A1

公开(公告)日：2022-07-07

申请号：US17602202

申请日：2020-09-23

Applicant: SOUTHEAST UNIVERSITY

Inventor： Ning GU ,  Xin LIU

IPC: A61L31/04

Abstract: The present invention relates to a method for molding a self-supporting silk fibroin catheter stent, which comprises preparing an excellent catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material. The raw material is silk fibroin extracted from natural mulberry silk; and the mold is a hollow tubular mold, having an outer shell that is a transparent polyethylene straw with a diameter of 6 mm and an inner core that is a fiber rod FRP with a diameter of 3 mm, with the two ends being closed. The mold casting and freeze-drying molding process comprises the steps of casting; pre-freezing; removing the mold and placing the mold onto a pre-frozen freeze-drying plate; and freeze-drying. The freeze-drying procedure comprises: (1) a pre-freezing stage; (2) a freezing—vacuum transition stage; (3) a gradient temperature-rising and freeze-drying stage; and (4) a secondary freeze-drying stage. The freeze-drying procedure is strictly regulated in accordance with the specifications of freeze-dried stents. The prepared stent has a good shape, and good tolerance without adding any additional components. The stent presents a three-dimensional porous space structure, the process is simple, and the stent meets the requirements for tissue-engineered vascular stent in clinic.

公开(公告)号：US20170202775A1

公开(公告)日：2017-07-20

申请号：US15510644

申请日：2015-10-23

Applicant: SOUTHEAST UNIVERSITY

Inventor： Ning GU ,  Jilai TIAN ,  Fang YANG ,  Juan JIN

IPC: A61K9/127 ,  A61K47/24 ,  A61K49/00

CPC classification number: A61K9/127 ,  A61K41/0028 ,  A61K47/24 ,  A61K47/6925 ,  A61K49/00 ,  A61K49/223

Abstract: A preparation method of lipid bubbles by utilizing the principle of natural adsorption and assembly of amphiphilic lipid molecules on a gas-liquid interface comprises the steps of mixing gas-dissolved water containing free bubbles with lipid materials, and then the lipid materials are dispersed in the free gas nanobubble aqueous solution, and, in the presence of free bubbles, adsorbed and assembled on the gas-liquid interfaces so as to form lipid bubbles. The method is different from the traditional ultrasound cavitation, the mechanical force action, the novel ink jet printing method, the microchannel method and other methods for preparing bubbles.