公开(公告)号：US20240409500A1

公开(公告)日：2024-12-12

申请号：US18812980

申请日：2024-08-22

Applicant: SOUTHEAST UNIVERSITY

Inventor： Shaohua GOU ,  Wanxiang YANG

IPC: C07C243/04 ,  A61K31/196 ,  A61P9/10

Abstract: Disclosed is NO donor compound and preparation method, pharmaceutical composition, and use. The compound has a structure represented by formula The NO donor compound and the pharmaceutical composition thereof, as hypoxia-activated NO donors, may be prepared as drugs for treating myocardial hypoxic damage disease. The prepared drugs can exert efficacy at both the cellular level and the animal level, and the synthesis method of the compound is simple and easy to operate.