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公开(公告)号：US20190133975A1
公开(公告)日：2019-05-09
申请号：US16242404
申请日：2019-01-08
Applicant: STC UNM
Inventor： Jeff Wade Hill
IPC: A61K31/138 , A61K31/325 , A61K9/00 , A61K45/06 , A61K31/27 , G01N33/50
Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.
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