公开(公告)号：US20150133515A1

公开(公告)日：2015-05-14

申请号：US14534993

申请日：2014-11-06

Applicant: STC.UNM

Inventor： ALEXANDRE CHIGAEV ,  LARRY A. SKLAR

IPC: G01N33/50 ,  A61K31/42 ,  A61K31/357 ,  A61K31/197

CPC classification number: G01N33/5041 ,  A61K31/195 ,  A61K31/197 ,  A61K31/357 ,  A61K31/36 ,  A61K31/42 ,  G01N33/5055 ,  G01N33/68 ,  G01N2333/70546 ,  G01N2333/7055 ,  G01N2500/04 ,  G01N2500/10

Abstract: This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery based upon induction of ligand-induced epitopes. Such ligands have the potential to be active agent as anti-inflammatory, anti-angiogenesis and/or anti-thrombotic agents and for the treatment of integrin mediated diseases and/or conditions.

Abstract translation: 本发明一般涉及整联蛋白配体发现和基于诱导配体诱导表位的整联蛋白配体发现的方法。 这样的配体具有作为抗炎，抗血管生成和/或抗血栓形成剂的活性剂的潜力，并且用于治疗整联蛋白介导的疾病和/或病症。