公开(公告)号：US20160237439A1

公开(公告)日：2016-08-18

申请号：US15029307

申请日：2014-10-10

Applicant: STC.UNM

Inventor： Fu-Sen LIANG

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N15/111 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/3233 ,  C12N2320/50 ,  C12Y301/00

Abstract: This disclosure describes modular miRNA regulator molecules and methods of using modular miRNA regulator molecules. Generally, the modular miRNA regulator molecules include a recognition module and an inhibition module. Generally, the recognition module includes a polynucleotide in which at least a portion of the polynucleotide recognizes at least a portion of a preselected pre-miRNA. Generally, the inhibition module includes a moiety that inhibits nuclease processing of the preselected pre-RNA to a mature RNA.

Abstract translation: 本公开描述了模块化miRNA调节剂分子和使用模块化miRNA调节剂分子的方法。 通常，模块化miRNA调节剂分子包括识别模块和抑制模块。 通常，识别模块包括多核苷酸，其中多核苷酸的至少一部分识别预选的前miRNA的至少一部分。 通常，抑制模块包括抑制核酸酶处理预选择的前RNA到成熟RNA的部分。