公开(公告)号：US10471047B2

公开(公告)日：2019-11-12

申请号：US16033008

申请日：2018-07-11

Applicant: STC.UNM

Inventor： Eric R. Prossnitz ,  Geetanjali Sharma

IPC: A61K31/436 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/16 ,  A61K31/7088 ,  A61K38/28

Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).

公开(公告)号：US20180318269A1

公开(公告)日：2018-11-08

申请号：US16033008

申请日：2018-07-11

Applicant: STC.UNM

Inventor： Eric R. Prossnitz ,  Geetanjali Sharma ,  Matthias Barton ,  Matthias R. Meyer

IPC: A61K31/436 ,  A61K31/4355 ,  A61K31/16 ,  A61K31/435 ,  A61K31/437

CPC classification number: A61K31/436 ,  A61K31/16 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/7088 ,  A61K38/28 ,  G01N2800/042

Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).