公开(公告)号：US10821167B2

公开(公告)日：2020-11-03

申请号：US16074886

申请日：2017-02-01

Applicant: STC.UNM

Inventor： Pamela Hall ,  Bryce Chackerian ,  David S. Peabody ,  Seth Michael Daly ,  Bradley Owen Elmore ,  Kathleen Triplett

IPC: C12Q1/68 ,  A61K39/085 ,  A61P37/04 ,  A61P31/04 ,  A61K39/00

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

公开(公告)号：US20190038735A1

公开(公告)日：2019-02-07

申请号：US16074886

申请日：2017-02-01

Applicant: STC.UNM

Inventor： Pamela Hall ,  Bryce Chackerian ,  David S. Peabody ,  Seth Michael Daly ,  Bradley Owen Elmore ,  Kathleen Triplett

IPC: A61K39/085 ,  A61P31/04 ,  A61P37/04

CPC classification number: A61K39/085 ,  A61K2039/52 ,  A61K2039/5258 ,  A61P31/04 ,  A61P37/04 ,  C12N2795/18123

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.