公开(公告)号：US20240076327A1

公开(公告)日：2024-03-07

申请号：US18258720

申请日：2021-12-21

Applicant: SYNGENTA CROP PROTECTION AG

Inventor： Aurelien BIGOT ,  Fides BENFATTI ,  David J. CRAIK ,  Yen-Hua HUANG ,  Quentin KAAS ,  Conan WANG

IPC: C07K14/435 ,  A01P7/04

CPC classification number: C07K14/43518 ,  A01P7/04

Abstract: The present invention relates to a hexatoxin peptide variant comprising a. an amino acid sequence which is at least 90% identical to any one of SEQ ID NOs: 27 to 29, wherein the amino acid sequence has at least one amino acid variant on position N27; b. an amino acid sequence which is at least 90% identical to any one of SEQ ID NOs: 2, 6, 7, 30 or 32, wherein the amino acid sequence has at least one amino acid variant on position N28; c. an amino acid sequence which is at least 90% identical to any one of SEQ ID NOs: 1, 3, 4, 5, 8 to 24 or 31, wherein the amino acid sequence has at least one amino acid variant on position N29; d. an amino acid sequence which is at least 90% identical to SEQ ID NO: 25, wherein the amino acid sequence has at least one amino acid variant on position N30; e. an amino acid sequence which is at least 90% identical to SEQ ID NOs: 26, wherein the amino acid sequence has at least one amino acid variant on position N31; or f. an amino acid sequence which is at least 90% identical to SEQ ID NO: 34, wherein the amino acid sequence has at least one amino acid variant on position N32; each of which retain the biological activity of the hexatoxin; with the proviso that the peptide does not comprise the amino acid sequence of SEQ ID NO: 33.

公开(公告)号：US20240049725A1

公开(公告)日：2024-02-15

申请号：US18258636

申请日：2021-12-21

Applicant: SYNGENTA CROP PROTECTION AG

Inventor： Aurelien BIGOT ,  Fides BENFATTI ,  David J. CRAIK ,  Yen-Hua HUANG ,  Quentin KAAS ,  Mark SCHIEBLER ,  Conan WANG

IPC: A01N63/50 ,  A01P7/04

CPC classification number: A01N63/50 ,  A01P7/04

Abstract: The present invention relates to an insecticidal composition comprising: a. at least one cyclic peptide comprising an amino acid sequence of any of: SEQ ID NOs: 1, 2 or 6, or an amino acid sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identical to any of SEQ ID NOs: 1, 2 or 6; and b. at least one second peptide comprising an amino acid sequence of any of SEQ ID NOs: 3 to 5, or an amino acid sequence that is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identical to any of SEQ ID NOs: 3 to 5, or a variant of a peptide comprising an amino acid sequence of SEQ ID NO: 3, wherein the amino acid sequence has an amino acid variant on position N29, and which retains the biological activity of the peptide.