公开(公告)号：US20240118272A1

公开(公告)日：2024-04-11

申请号：US18469093

申请日：2023-09-18

Applicant: SYSMEX CORPORATION

Inventor： Eiya TAMADA ,  Masatoshi Yanagida ,  Kazuto Yamashita ,  Elnaz Nakhael ,  Mami Onishi ,  Maria Kiriyama

IPC: G01N33/543 ,  C07K14/705 ,  C07K16/28

CPC classification number: G01N33/54333 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2896 ,  G01N2333/916 ,  G01N2496/00

Abstract: Disclosed is a method for measuring an activity of alkaline phosphatase contained in an extracellular vesicle in a sample, including acquiring an activity value of alkaline phosphatase contained in an extracellular vesicle in a sample using a calibrator, in which the calibrator contains a conjugate in which a polypeptide having alkaline phosphatase activity and a polypeptide including an amino acid sequence of a membrane protein present on a surface of the extracellular vesicle are covalently bound.