公开(公告)号：US20230285417A1

公开(公告)日：2023-09-14

申请号：US18006141

申请日：2021-07-20

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  Padma Narayan ,  Xiaoxia Chen ,  Todd Anthony Stutzman ,  Jianing Meng ,  Carolyn Wilkerson ,  Raj Ramnik Jain

IPC: A61K31/58 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K31/58 ,  A61K9/1694 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1623 ,  A61K9/1617 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2018 ,  A61K9/2013 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and pharmaceutical compositions thereof. Also disclosed herein are methods of making the pharmaceutical compositions of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

公开(公告)号：US20230057130A1

公开(公告)日：2023-02-23

申请号：US17579541

申请日：2022-01-19

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  Padma Narayan ,  Xiaoxia Chen ,  Todd Anthony Stutzman ,  Jianing Meng ,  Carolyn Wilkerson ,  Raj Ramnik Jain

IPC: A61K31/58 ,  A61K9/20 ,  A61K9/48

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and pharmaceutical compositions thereof. Also disclosed herein are methods of making the pharmaceutical compositions of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.